Stable cyclosporine containing ophthalmic emulsion for treating dry eyes
Disclosed herein are stable oil-in-water emulsion ophthalmic topical liquid compositions having an average particle size less than 1 μm including at least one plant-derived oil other than castor oil...
View ArticleCompositions and methods for hair growth
The present invention is directed to compositions and methods comprising the use of bimatoprost and cyclosporine, used concurrently and in combination, to grow hair and for the treatment of all types...
View ArticleDeuterated cyclosporine analogs and methods of making the same
Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporin and cyclosporine derivatives. The...
View ArticleCrystalline form of cyclosporine a, methods of preparation, and methods for...
The present invention relates generally to crystalline forms of cyclosporine A and particularly to a newly identified form of cyclosporine A. The invention further relates to methods for its...
View ArticleCombination therapies using cyclosporine and aromatic cationic peptides
The invention provides compositions and methods for preventing or treating an ischemia-reperfusion injury, such as occurs during acute myocardial infarction and organ transplant in a mammalian...
View ArticleCyclosporine analogue mixtures and their use as immunomodulating agents
The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the...
View ArticleMethods for inhibiting growth of prolactin-responsive cancer cells with...
Methods are provided for inhibiting growth of prolactin-responsive cancer cells and treating prolactin-responsive malignancies via administration an agent such as cyclosporine A which directly...
View ArticleNonimmunosuppressive cyclosporine analogue molecules
The compounds of the present invention are non-immunosupressive cyclosporine analogue molecules that are able to bind cyclophilin. Said compounds include a modified side chain of amino acid I of...
View ArticleDevice for reducing renal sympathetic nerve activity
The present invention provides devices and methods for modulating or blocking renal sympathetic nerve activity by applying laser energy to the renal artery wall to effect ablation of the renal nerve...
View ArticleCyclosporine analogue mixtures and their use as immunomodulating agents
The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the...
View ArticleCyclosporine analogue molecules modified at amino acid 1 and 3
Analogues of cyclosporin-A are disclosed comprising modifications of the substituents as the positions of amino acids 1 and 3, according to the following Formula. The disclosed compounds include...
View ArticleMethods to treat cancer using cyclosporine and cyclosporine derivatives
Methods to treat certain types of cancer with cyclophilin inhibitors....
View ArticleNovel [n-me-4-hydroxyleucine]-9-cyclosporin analogues for treatment and...
The present invention relates to novel cyclosporine analogues having antiviral activity against HCV and useful in the treatment of HCV infections. More particularly, the invention relates to novel...
View ArticleDeuterated cyclosporine analogs and methods of making the same
Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The...
View ArticleCyclosporine a steroid conjugates
The present invention describes Cyclosporine A/steroid hybrid analogs. These single drug entities are formed by connecting a steroid with Cyclosporine A. Upon topical application to the eye, the...
View ArticleCompositions and methods for predicting hcv susceptibility to antiviral agents
Provided herein are methods for determining the susceptibility of a hepatitis C virus (HCV) in a patient to anti-viral agents, particularly cyclophilin inhibitors such as cyclosporine A. More...
View ArticleSynthesis of cyclosporin analogs
The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the...
View ArticleOphthalmic composition containing cyclosporine and method for preparing same
The present invention relates to an ophthalmic composition containing cyclosporine as an active ingredient and comprising propylene glycol, a surfactant, and purified water, and to a method for...
View ArticleCrystalline form of cyclosporine a, methods of preparation, and methods for...
The present invention relates generally to crystalline forms of cyclosporine A and particularly to a newly identified form of cyclosporine A. The invention further relates to methods for its...
View ArticleCombination therapies using cyclosporine and aromatic cationic peptides
The invention provides compositions and methods for preventing or treating an ischemia-reperfusion injury, such as occurs during acute myocardial infarction and organ transplant in a mammalian...
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